Table 2 Adjusted hazard ratios of mortality by cluster in the different groups. Models were adjusted for age, sex, BMI categories, deprivation quintiles, smoking status, ethnicity, and opioid use in the first 12 months of OA diagnosis

All OA

3

Ref

1

1.44

<0.001

1.36

1.51

2

1.52

<0.001

1.47

1.57

4

1.16

<0.001

1.13

1.20

5

1.22

<0.001

1.16

1.28

6

2.09

<0.001

2.01

2.17

Hand OA

3

Ref

1

1.71

<0.001

2.27

2.27

2

1.55

<0.001

1.30

1.85

4

1.09

0.243

0.94

1.27

5

1.14

0.386

0.85

1.53

6

2.53

<0.001

2.05

3.13

Hip/knee OA

3

Ref

1

1.37

<0.001

1.25

1.50

2

1.71

<0.001

1.62

1.80

4

1.12

<0.001

1.06

1.17

5

1.02

0.751

0.91

1.13

6

1.33

<0.001

1.24

1.42

Controls

3

Ref

1

1.24

<0.001

1.12

1.39

2

1.47

<0.001

1.40

1.54

4

1.12

<0.001

1.08

1.17

5

0.92

0.101

0.84

1.01

6

1.70

<0.001

1.61

1.80