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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Single-cell analysis reveals heterogeneity of juvenile idiopathic arthritis fibroblast-like synoviocytes with implications for disease subtype

Fig. 3

Cluster dispersion increases with disease course severity. Cells in oligoarticular mostly cluster together and begin to separate in ETB samples. The greatest dispersion is seen in the polyarticular samples (A). Cells were automatically annotated using the SingleR data package from Bioconductor. Shared populations between JIA subtypes included fibroblast-like cells, chondrocyte-like cells, and smooth muscle cell-like cells, as well as smaller subpopulations (B). Seurat single analysis identified the top genes of each projected cell type for each subtype. These genes are the highest contributors to variation among the cells. Genes that contribute the most variation among cells are as follows: oligo — COL1A1, MT-ND1, TUBA1B, ACAN, and IFI27; ETB — MTRNR2LB, SERPINE1, TOP2A, MEG3, COL3A1, and VCAM; and poly — ACP5, SPP1, TNFAIP6, IGFBP5, AKAP12, MFAP5, and S100A4 (C)

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Arthritis Research & Therapy

ISSN: 1478-6362

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