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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Single-cell analysis reveals heterogeneity of juvenile idiopathic arthritis fibroblast-like synoviocytes with implications for disease subtype

Fig. 6

Chondrocyte-like cell subpopulation between JIA subtypes. LRRC15 is expressed in 35.8% of chondrocyte-like cells in oligo JIA FLS and 6.1% in ETB JIA FLS. 67.3% of chondrocyte-like cells in oligo JIA FLS express GREM1 compared to 34.8% in ETB JIA FLS. GREM2 is expressed in 45.8% of the chondrocyte-like cells in oligo JIA FLS compared to 11.5% in ETB JIA FLS (A). S100A4 is expressed in 89.6% of chondrocyte-like cells in ETB JIA FLS compared to 39% in poly JIA FLS. 75.8% of chondrocyte-like cells in ETB JIA FLS express TIMP3 compared to 48.2% in poly JIA FLS. NBL1 is expressed in 72.4% of the chondrocyte-like cells in ETB JIA FLS compared to 40.7% poly JIA FLS subpopulation from poly JIA FLS (B). CRLF1 is expressed in 63.1% of chondrocyte-like cells in oligo JIA FLS compared to 29.2% in poly JIA FLS. 58.7% of chondrocyte-like cells in oligo JIA FLS express MFAP5 compared to 19.7% in poly JIA FLS. TNXB is expressed in 44.6% of the chondrocyte-like cells in oligo JIA FLS compared to 11.6% in poly JIA FLS (C). p-values were < 0.01

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