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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Therapeutic effects of adipose-derived mesenchymal stem/stromal cells with enhanced migration ability and hepatocyte growth factor secretion by low-molecular-weight heparin treatment in bleomycin-induced mouse models of systemic sclerosis

Fig. 1

Cellular functions of mASCs from Balb/c mice activated with different concentrations of LMWH. A The migration activity of mASCs with 10 and 100 μg/mL LMWH was significantly increased and that with 1 μg/mL LMWH was not increased. B The proliferation activity of mASCs in various concentrations of LMWH showed no significant difference. C The amounts of HGF secreted by mASCs with 1, 10, and 100 μg/mL LMWH were significantly increased. D–F The mRNA expression of chemokine SDF-1, CXCR-4, and CXCR-7 were significantly upregulated in mASCs with 100 μg/mL LMWH, and not in mASCs with 1 and 10 μg/mL LMWH. Data are shown as mean ± standard error of mean (SEM). *P < 0.05; **P < 0.01 vs. mASCs without LMWH

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