Fig. 3
From: Senescence-accelerated mice prone 8 (SAMP8) in male as a spontaneous osteoarthritis model
Aging-associated pathological changes in meniscus, synovium, and cruciate ligament. A H&E and safranin O staining of the medial meniscus in SAMR1 and SAMP8 at 11 and 14 weeks of age. B Histopathologic meniscus scores in medial and lateral knee menisci of left knee joints in SAMR1 and SAMP8 at 6 to 33 weeks of age. C H&E staining of the synovium in SAMR1 and SAMP8 at 14, 18, and 23 weeks of age. D Histopathologic scores in synovium in SAMR1 and SAMP8 at 6 to 33 weeks of age. E Safranin O staining of the cruciate ligament in SAMR1 and SAMP8 at 14, 18, and 23 weeks of age. All data are represented as median with 95% confidence interval were compared between SAMR1 and SAMP8 in aging analysis by Mann–Whitney U test at each time point. The p-values (#P < 0.05, ##P < 0.01) were corrected by using Holm’s method for multiple comparison correction