Fig. 4
From: Senescence-accelerated mice prone 8 (SAMP8) in male as a spontaneous osteoarthritis model
Analysis of subchondral area and femur metaphysis in SAMP8 with aging. A Histopathologic scores of subchondral bone in the medial tibia of SAMR1 and SMP8 at 4, 6, 9, 14, 18, 23, 28, and 33 weeks of age. Data are represented as median with 95% confidence interval were compared between SAMR1 and SAMP8 in aging analysis by Mann–Whitney U test at each time point. The p-values (##P < 0.01) were corrected by using the Holm’s method for multiple comparison correction. B Representative images of μCT and colored μCT with calcium phosphate from the same SAMP8 and SAMR1 at 4, 6, 9, and 23 weeks of age (n = 5 for each strain). C Graphs representing the parameters (bone volume (BV/TV), Tb.N (1/mm), trabecular thickness (Tb.Th, μm), and trabecular separation (Tb.Sp, μm)) of subchondral bone region of the medial tibia on μCT analysis. D μCT images of the metaphysis of the distal femur in SAMP8 and SAMR1 at 4, 6, 9, and 23 weeks of age (n = 4–5 for each strain). E Graphs representing the parameters of the metaphyseal region on μCT analysis. Data are represented as mean ± S.D. Comparison of mean values was performed using Welch’s t test. The p-values (#P < 0.05, ##P < 0.01) were corrected using the Holm-Sidak correction