Table 2 The associations between gout and significant variants of chromosome 1 in replication cohort
SNP (chr; position; gene) | Gout | Control | OR (95% CI) | p-values |
|---|---|---|---|---|
rs7546668 (chr1; 15528628; DNAJC16) | ||||
 GG | 55 (27.0) | 89 (18.8) | 2.77 (1.69-4.56) | 4.31e-05 |
 GC | 114 (55.9) | 227 (48.0) | 2.25 (1.47 -3.46) | 1.74e-04 |
 CC | 35 (17.2) | 157 (33.2) | 1.0 |  |
rs12124078 (chr1; 15543404; DNAJC16) | ||||
 AA | 55 (26.8) | 90 (19.0) | 2.60 (1.58-4.26) | 1.22e-04 |
 AG | 114 (55.6) | 230 (48.6) | 2.11 (1.37-3.23) | 5.38e-04 |
 GG | 36 (17.6) | 153 (32.3) | 1.0 |  |
rs7515244 (chr1;15546891; DNAJC16) | ||||
 AA | 55 (26.8) | 91 (19.2) | 2.58 (1.57-4.21) | 1.45e-04 |
 AG | 114 (55.6) | 229 (48.4) | 2.12 (1.38-3.24) | 4.99e-04 |
 GG | 36 (17.6) | 153 (32.3) | 1.0 |  |
rs10927807 (chr1; 15584515; AGMAT) | ||||
 TT | 66 (32.4) | 74 (15.6) | 4.34 (2.68-7.02) | 6.62e-10 |
 TG | 100 (49.0) | 214 (45.2) | 2.28 (1.49-3.47) | 1.09e-04 |
 GG | 38 (18.6) | 185 (39.1) | 1.0 |  |
rs12129861 (chr:1; 145709377; PDZK1) | ||||
 TT | 10 (4.90) | 31 (6.55) | 0.62 (0.30 -1.31) | 0.206 |
 CT | 56 (27.45) | 176 (37.21) | 0.61 (0.43-0.88) | 0.008 |
 CC | 138 (67.65) | 266 (56.24) | 1.0 |  |
rs1471633 (chr:1; 145711327; PDZK1) | ||||
 GG | 10 (4.88) | 23 (4.86) | 0.86 (0.40 -1.86) | 0.708 |
 TG | 50 (24.39) | 162(34.25) | 0.61 (0.42 -0.89) | 0.010 |
 TT | 145 (70.73) | 288(60.89) | 1.0 |  |
rs1967017 (chr:1;145711421; PDZK1) | ||||
 GG | 10(4.88) | 23(4.86) | 0.86 (0.40-1.86) | 0.708 |
 AG | 50(24.39) | 162(34.25) | 0.61 (0.42-0.89) | 0.010 |
 AA | 145(70.73) | 288(60.89) | 1.0 |  |
rs35880546 (chr:1;145722014; CD160) | ||||
 GG | 8(3.90) | 15(3.17) | 1.07 (0.44-2.57) | 0.886 |
 AG | 44(21.46) | 152(32.14) | 0.58 (0.39-0.85) | 0.005 |
 AA | 153(74.63) | 306(64.69) | 1.0 |  |
rs4970874 (chr:1;145725691; CD160) | ||||
 GG | 8(3.90) | 15(3.17) | 1.07 (0.44-2.57) | 0.886 |
 AG | 44(21.46) | 152(32.14) | 0.58 (0.39-0.85) | 0.005 |
 AA | 153(74.63) | 306(64.69) | 1.0 |  |
rs1471630 (chr:1;145727789; CD160) | ||||
 CC | 8(3.90) | 15(3.17) | 1.07 (0.44-2.57) | 0.886 |
 TC | 44(21.46) | 152(32.14) | 0.58 (0.39-0.85) | 0.005 |
 TT | 153(74.63) | 306(64.69) | 1.0 |  |
rs9286836 (chr:1;145846532; NUDT17) | ||||
 A/A | 110(53.66) | 17(3.59) | 39.75 (21.96-71.94) | 5.47e-50 |
 A/C,G | 46(22.44) | 155(32.77) | 1.82 (1.17-2.85) | 0.008 |
 C,G/C,G | 49(23.90) | 301(63.64) | 1.0 |  |
rs11264341 (chr:1;155179017; TRIM46) | ||||
 CC | 68(33.17) | 47(9.94) | 7.12 (4.39-11.53) | 2.77e-17 |
 CT | 88(42.93) | 185(39.11) | 2.34 (1.57-3.48) | 2.24e-05 |
 TT | 49(23.90) | 241(50.95) | 1.0 |  |
rs4971100 (chr:1;155183255; TRIM46) | ||||
 GG | 74(36.27) | 39(8.25) | 10.53 (6.43-17.24) | 3.35e-24 |
 GA | 81(39.71) | 162(34.25) | 2.78 (1.85-4.16) | 4.52e-07 |
 AA | 49(24.02) | 272(57.51) | 1.0 |  |
rs4072037 (chr:1;155192276; MUC1) | ||||
 CC | 85(41.46) | 29(6.13) | 17.13 (10.23-28.68) | 2.87e-34 |
 CT | 69(33.66) | 146(30.87) | 2.76 (1.83-4.17) | 8.37e-07 |
 TT | 51(24.88) | 298(63.00) | 1.0 |  |
rs2974935 (chr:1;155212052; MTX1) | ||||
 GG | 86(42.16) | 28(5.92) | 17.67 (10.52-29.65) | 1.05e-34 |
 GT | 66(32.35) | 146(30.87) | 2.60 (1.72-3.93) | 4.05e-06 |
 TT | 52(25.49) | 299(63.21) | 1.0 |  |
rs80142782 (chr:1;155515236; ASH1L) | ||||
 CC | 2(0.98) | 9(1.90) | 0.55 (0.12-2.57) | 0.439 |
 TC | 53(25.85) | 94(19.87) | 1.39 (0.95-2.05) | 0.094 |
 TT | 150(73.17) | 370(78.22) | 1.0 |  |