Fig. 4From: Cationic amino acid transporter-1 (CAT-1) promotes fibroblast-like synoviocyte proliferation and cytokine secretion by taking up L-arginine in rheumatoid arthritisKnockdown CAT-1 suppresses cell proliferation. a The growth curve of RA FLSs transfected with CAT1-siRNA or treated with D-arginine and cultured under normoxic or hypoxic conditions, as determined by MTT assay. b Cell cycle analysis G1/S transition of RA FLSs transfected with CAT1-siRNA or treated with D-arginine and cultured under normoxic or hypoxic conditions, as determined by flow cytometry. c Quantification of cell cycle analysis. The data are expressed as the mean ± SD of three independent experiments. *P < 0.05Back to article page