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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Cationic amino acid transporter-1 (CAT-1) promotes fibroblast-like synoviocyte proliferation and cytokine secretion by taking up L-arginine in rheumatoid arthritis

Fig. 4

Knockdown CAT-1 suppresses cell proliferation. a The growth curve of RA FLSs transfected with CAT1-siRNA or treated with D-arginine and cultured under normoxic or hypoxic conditions, as determined by MTT assay. b Cell cycle analysis G1/S transition of RA FLSs transfected with CAT1-siRNA or treated with D-arginine and cultured under normoxic or hypoxic conditions, as determined by flow cytometry. c Quantification of cell cycle analysis. The data are expressed as the mean ± SD of three independent experiments. *P < 0.05

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