Fig. 1

The level of PSTPIP2 in synovial macrophages is negatively correlated with RA disease activity, which was mediated by synovial macrophages polarization. A DAS28 score of 23 RA patients, including 5 single-onset type, 6 concealed type, 6 recurrent type, and 6 persistently progressive types. B The expression of PSTPIP2 in peripheral blood CD11b⁺ monocytes of 5 healthy control and 23 RA patients. C The expression of PSTPIP2 in CD11b⁺ synovial macrophages of 5 healthy control and 5 persistently progressive RA patients. D Immunohistochemical staining of synovial tissues in 5 healthy control and 5 persistently progressive RA patients. E Immunofluorescence double staining of synovial tissues in 5 healthy control and 5 persistently progressive RA patients. F Correlation analysis of PSTPIP2 level in peripheral blood CD11b⁺ monocytes with DAS28 in 23 RA patients. G Correlation analysis of PSTPIP2 level in CD11b⁺ synovial macrophages with DAS28 in 5 persistently progressive RA patients. H Scatter plot (left) and histogram (right) of CD11b⁺CD206⁺ cells in peripheral blood. I Scatter plot (left) and histogram (right) of CD11b⁺CD206⁺ cells in synovial tissue. J Correlation analysis of the level of PSTPIP2 in CD11b⁺ monocytes with CD11b⁺CD206⁺ cells in peripheral blood. K Correlation analysis of the level of PSTPIP2 in CD11b⁺ monocytes with CD11b⁺CD206⁺ cells in synovial tissue. P < 0.05 indicates that the difference is statistically significant. Data represent mean ± SD (unpaired t test for D, H, and I; linear regression for F, G, J, and K)