Skip to main content
Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: PSTPIP2 regulates synovial macrophages polarization and dynamics via ERβ in the joint microenvironment

Fig. 2

PSTPIP2hi synovial macrophages form a tight immunological barrier in the lining layer. A SafraninO-fast green staining and F4/80 fluorescence staining of synovial tissue in normal controls, Pstpip2CreR26-ZsGreen reporter mice, and wild mice on day 35. PSTPIP2 (green), F4/80 (red), and DAPI (blue); sc, synovial cavity; st, synovial tissue. B SafraninO-fast green staining and CD206 fluorescence staining of synovial tissue in normal controls, Pstpip2CreR26-ZsGreen reporter mice, and wild mice on day 70. C Scatter plot of PSTPIP2hiCD206+ synovial macrophages in synovial tissue on day 35. D Scatter plot of PSTPIP2hiCD206+ synovial macrophages in synovial tissue on day 70. E Histogram of PSTPIP2hiCD206+ synovial macrophages in synovial tissue on day 35 and day 70. F Scatter plot of claudin5 expression in F4/80+PSTPIP2+ synovial macrophages on day 35. G Scatter plot of claudin5 expression in F4/80+PSTPIP2+ synovial macrophages on day 70. H Histogram of F4/80+PSTPIP2+ synovial macrophages in synovial tissue on day 35 and day 70. I Histogram of F4/80+PSTPIP2+claudin5+ synovial macrophages in synovial tissue on day 35 and day 70. P < 0.05 indicates that the difference is statistically significant. Data represent mean ± SD (unpaired t test for E, H, and I)

Back to article page