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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Rheumatoid arthritis sera antibodies to citrullinated collagen type II bind to joint cartilage

Fig. 2

The sera reactivity to cyclic COL2 peptides and native triple-helical COL2. A Promiscuous sera showed higher reactivity to ACC10 while the private showed higher specificity but relatively low reactivity. Dash line separates arginine peptides (left) and ACC10 (right). ***P < 0.001, *P < 0.05; ns, no significance. B Sera response to native triple-helical COL2 in × 40 and × 100 diluted ratio. C Anti-CCP test for RA patients was detected using commercial EuroDiagnostica, RA-96PLUS kit. Absorbance ratio < 0.95 is defined as negative and > 1.0 as positive. pro-, promiscuous; pri-, private; HC, healthy individuals sera

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