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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Rheumatoid arthritis sera antibodies to citrullinated collagen type II bind to joint cartilage

Fig. 3

Sera presented different reactivity to other antigen peptides (A) and triple-helical COL2 peptides (B). Promiscuous sera showed a higher reactivity to fib cit 617-635, CEP-1, CCP-1, and vim cit 58-77 compared with the private (C). As for triple-helical COL2 peptides (D), promiscuous sera also show cross-reactivity to citrullinated E10, D3, J1, U1, C1, and F4 petides. Private sera almost had no reactivity to triple-helical COL2 peptides except for pri-RA1. ***P < 0.001, **P < 0.01, *P < 0.05; ns, no significance. pro-RA, promiscuous RA sera; pro-OA, promiscuous OA sera; pri-RA, private RA sera; pri-OA, private OA sera

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