A | Age at HSCT<50y | Age at HSCT≥50y | B | Time Dg to HSCT <3y | Time Dg to HSCT ≥3y | ||
---|---|---|---|---|---|---|---|
n | 57 (76%) | 18 (24%) | p | 43 (56%) | 34 (44%) | p | |
female | 32 (56%) | 9 (50%) | 0.787 | 18 (42%) | 23 (68%) | 0.035 | |
male | 25 (44%) | 9 (50%) | 24 (56%) | 10 (29%) | |||
Age at Dg (mean ± SD) | 33.9 ± 8.9 | 52.9 ± 5.7 | <0.001 | 41.1 ± 11.6 | 35.0 ± 10.9 | 0.018 | |
Age at HSCT | 38.5 ± 8.2 | 57.3 ± 3.7 | n.a. | 43.2 ± 11.6 | 42.9 ± 10.2 | 0.949 | |
Time Dg to HSCT | 4.2 ± 4.8 | 3.8 ± 4.6 | 0.794 | 1.6 ± 0.8 | 7.4 ± 5.6 | n.a. | |
diffuse cutaneous SSc | 52 (91%) | 14 (78%) | 0.160 | 41 (95%) | 27 (79%) | 0.042 | |
mRSS at HSCT | 17.7 ± 11.7 | 19.4 ± 12.7 | 0.579 | 20.8 ± 11.5 | 14.5 ± 11.4 | 0.015 | |
DLCO-SB at HSCT | 56.0 ± 15.9 | 46.8 ± 18.4 | 0.261 | 52.3 ±17.0 | 55.6 ± 19.4 | 0.567 | |
fVC at HSCT | 73.8 ± 21.4 | 81.0 ± 18.4 | 0.261 | 76.1 ± 16.5 | 75.4 ± 24.8 | 1.000 | |
ILD with PAH n(%) | 5 / 56 (9%) | 6 / 18 (33%) | 0.024 | 7 / 42 (17%) | 4 / 34 (12%) | 0.328 | |
Heart involvement | 12 / 56 (21%) | 7 / 18 (39%) | 0.213 | 15 / 42 (36%) | 4 / 34 (12%) | 0.019 | |
Time HSCT to last f-up | 6.9 ± 4.8 | 4.3 ± 4.2 | 0.025 | 6.2 ± 4.7 | 7.0 ± 5.4 | 0.652 | |
Alive at last f-up | 54 / 57 (95%) | 15 / 18 (83%) | 0.145 | 38 / 43 (88%) | 33 / 34 (97%) | 0.220 | |
Dead at last f-up | 3 / 57 (5%) | 3 / 18 (17%) | 5 / 43 (12%) | 1 / 34 (3%) |