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Table 1 Patient characteristics

From: Four emerging immune cellular blood phenotypes associated with disease duration and activity established in Psoriatic Arthritis

 

All

(n=70)

TNFi

(n=30)

IL17

(n=20)

MTX

(n=20)

p-value

Female

39 (55.71)

17 (56.67)

12 (60.00)

10 (50.00)

0.811

Age, years

51.50 (45.23-61.23)

49.25 (41.83-59.12)

50.15 (45.17-61.95)

56.80 (51.35-62.38)

0.133

Disease duration, years

4.00 (1.58-10.00)

3.67 (1.56-8.31)

7.75 (1.65-14.25)

3.13 (1.44-10.75)

0.645

Treatment

Previous bDMARD

 Bio-naïve

40 (57.14)

20 (66.67)

2 (10.00)

18 (90.00)

< 0.001

 1

15 (21.43)

7 (23.33)

6 (30.00)

2 (10.00)

 2

8 (11.43)

2 (6.67)

6 (30.00)

0 (0.00)

 3

3 (4.29)

0 (0.00)

3 (15.00)

0 (0.00)

 4

3 (4.29)

1 (3.33)

2 (10.00)

0 (0.00)

 5

1 (1.43)

0 (0.00)

1 (5.00)

0 (0.00)

Concomitant csDMARD

22 (31.43)

13 (43.33)

9 (45.00)

0 (0.00)

0.016

Clinical phenotypes

 DAPSA

29.20 (21.80-39.90)

27.90 (21.85-39.73)

36.70 (26.00-47.45)

27.55 (20.50-36.83)

0.187

 PASI

1.20 (0.00-3.30)

1.50 (0.30-3.40)

0.08 (0.00-2.83)

0.95 (0.00-2.93)

0.570

 PsA without psoriasis

22 (31.43)

8 (26.67)

8 (40.00)

6 (30.00)

0.469

 Dactylitis

16 (22.86)

6 (20.00)

6 (30.00)

4 (20.00)

0.869

 Enthesitis

54 (77.14)

24 (80.00)

16 (80.00)

14 (70.00)

0.553

 Nail psoriasis

43 (61.43)

19 (63.33)

10 (50.00)

14 (70.00)

0.383

Immune cellular frequency

 CD8+ T cells, %

19.98 (15.12-25.27)

21.02 (18.63-25.76)

18.51 (13.14-23.44)

17.70 (14.96-23.11)

0.086

 Th1 cells, %

1.79 (1.28-2.96)

1.79 (1.50-3.43)

2.25 (1.48-2.94)

1.44 (1.05-2.47)

0.239

 Th17 cells, %

3.32 (2.40-4.61)

3.25 (2.45-4.50)

3.73 (3.09-5.03)

2.81 (2.29-3.36)

0.089

 nTregs, %

1.21 (0.87-1.48)

1.22 (0.98-1.56)

1.13 (0.78-1.50)

1.24 (0.82-1.44)

0.773

 uamTregs, %

1.13 (0.89-1.50)

1.13 (0.95-1.42)

1.23 (0.86-1.62)

1.07 (0.79-1.56)

0.942

 amTregs, %

0.38 (0.22-0.57)

0.36 (0.23-0.58)

0.51 (0.21-0.63)

0.36 (0.25-0.49)

0.760

 Dendritic cells, %

1.21 (0.76-1.82)

1.30 (0.77-1.59)

1.18 (0.79-1.86)

1.10 (0.72-2.18)

0.900

 NK cells, %

7.42 (5.04-9.69)

6.87 (5.16-9.18)

5.80 (4.00-8.69)

9.14 (6.07-11.41)

0.186

 Monocytes, %

3.79 (2.08-5.41)

3.66 (2.03-4.85)

3.50 (2.11-5.13)

4.03 (3.41-8.13)

0.352

  1. Patient demographics and treatment characteristics were presented as medians with corresponding interquartile range (IQR) for continuous variables and number of patients with corresponding percentage for categorical variables. Immune cellular frequencies were given as the median percentage of the lymphocyte population with corresponding IQR
  2. bDMARD biological Disease Modifying Anti-rheumatic Drug, csDMARD conventional synthetic Disease Modifying Anti-Rheumatic Drug, DAPSA Disease Activity for Psoriatic Arthritis, PASI Psoriasis Area and Severity Index, Th T helper, nTregs naïve T regulatory cells, uamTregs unactivated memory T regulatory cells, amTregs Activated Memory Tregs, NK cells Natural Killer cells