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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Axl regulated survival/proliferation network and its therapeutic intervention in mouse models of glomerulonephritis

Fig. 6

Molecular pathways regulated by Axl in glomerular nephritis. A Heat map of the expression patterns of responsive genes. Expression levels were centered by subtracting the average expression levels of a gene across all samples. Key molecular pathways altered in B6 nephritic kidney compared to B6 normal controls (B) and in B6.Axl-KO nephritic kidney compared to B6 nephritic kidney (C). D. PI3K pathway regulated IL-6 expression in nephritic mice from RNA-seq analysis. Values used in coloring pathway nodes were -log10 (fdr levels of the different expression), multiple by − 1 if the expression ratio was less than 1

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