Fig. 4

Results of semi-quantitative histological scoring for males (left) and females (right). All OARSI scores were determined based on the tibial region of the joint. A In males, medial compartment OARSI scores increased in both normotensive-MCLT+MMT and hypertensive-MCLT+MMT animals compared to their sham controls. B In females, this increase in medial compartment OARSI scores for the MCLT+MMT groups was also observed. C, D Lateral compartment OARSI scores did not change in any group. E In males, low-grade synovitis was present in both MCLT+MMT groups. F In females, low-grade synovitis was present in both MCLT+MMT groups, with hypertensive-MCLT+MMT animals having higher synovitis scores than normotensive-MCLT+MMT animals. Bars represent p < 0.05 the between groups. Black dots represent the outliers of the boxplots, while colored dots represent the individual data points. Data are presented as median and interquartile range