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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Individual immune cell and cytokine profiles determine platelet-rich plasma composition

Fig. 3

2D and 3D cell cultures of primary human chondrocytes exposed to a pro-inflammatory environment. a Population doublings dependent on IFN-γ and b TNF-α at indicated concentrations, c metabolic activity dependent on IFN-γ and d TNF-α at indicated concentrations, e lactate dehydrogenase (LDH) release dependent on IFN-γ and f TNF-α at indicated concentrations, fold change in mRNA expression relative to control of gACAN, hCOL1A1, and iCOL2A1 and delta threshold cycles of jMMP3, kMMP9, and lMMP13 dependent on IFN-γ and TNF-α treatment, respectively. Abbreviations: PD, population doublings; CTRL, control; rel, relative; IFN-γ, interferon γ; TNF-α, tumor necrosis factor α; LDH, lactate dehydrogenase; ACAN, aggrecan; COL1A1, collagen type 1A1; COL2A1, collagen type 2A1; MMP3, matrix metalloproteinase 3; MMP9, matrix metalloproteinase 9; MMP13, matrix metalloproteinase 13; ∆CT, delta cycle threshold

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