Parameter | High dose (n = 44) | Routine dose (n = 47) | p value |
---|---|---|---|
Vitamin D at 6 months Median (IQR) ng/ml | 34.12 (15.4) | 34.61 (12.7) | 0.16 |
Change in vitamin D over 6 months Median (IQR) ng/ml | 9.5 (14.5) | 2.6 (14.6) | 0.04 |
Vitamin D deficient at baseline (< 20 ng/ml) | 13 | 13 | 0.88 |
Vitamin D insufficient at baseline (20.1–29.9 ng/ml) | 20 | 20 | |
Vitamin D sufficient at baseline (≥ 30 ng/ml) | 11 | 14 | |
Vitamin D deficient at 6months (< 20 ng/ml) | 6 | 2 | 0.021 |
Vitamin D Insufficient at 6months (21–29 ng/ml) | 10 | 23 | |
Vitamin D sufficient at 6months (≥ 30 ng/ml) | 28 | 22 | |
Vitamin D levels improved | 22 | 20 | 0.76 |
Vitamin D levels remained same | 18 | 22 | |
Vitamin D worsened | 4 | 5 | |
Any Flare | 8 | 6 | 0.37 |
Major flare | 4 | 1 | 0.17 |
Minor flare | 4 | 5 | 0.51 |
SLEDAI 2KG 6 months Median (IQR) | 2 (4) | 2 (2) | 0.76 |
Δ SLEDAI 2KG median (min, max) | 0 (− 4, 9) | 0 (–4, 5) | 0.81 |
C3 (mg/dl) median (IQR) | 100.3 (35) | 104 (32) | 0.32 |
ΔC3 (mg/dl) median (IQR) | – 5.5 (24.9) | + 2 (52) | 0.59 |
C4 (mg/dl) median (IQR) | 17.3 (11) | 17.7 (10) | 0.98 |
Δ C4 (mg/dl) median (IQR) | – 2.4 (7.9) | – 0.7 (6.6) | 0.59 |
Low complements (C3/C4) | 12 | 14 | 0.82 |
Improved C3/C4 | 6 | 4 | 0.75 |
Worsened C3/C4 | 6 | 7 | |
Anti-dsDNA median (IQR) | 14.11 (51) | 48.2 (135) | 0.08 |
Δ Anti-dsDNA median (IQR) | – 15.2 (50.02) | – 2.8 (72.4) | 0.06 |
Positive anti-dsDNA | 7 | 16 | 0.87 |
Normalised anti-dsDNA (baseline positive- 6 months negative) | 19 | 11 | 0.14 |
Worsening anti-dsDNA (negative at baseline and positive at 6 months) | 2 | 4 |