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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Improved joint and patient-reported health assessments with pegloticase plus methotrexate co-therapy in patients with uncontrolled gout: 12-month exploratory outcomes of the MIRROR open-label trial

Fig. 3

Clinical and patient-reported measures (A–C) and coincident DECT imaging (D) in a 44-year-old man with uncontrolled gout who underwent pegloticase + methotrexate co-therapy for 52 weeks. Marked improvements in quality of life measures were observed as urate load decreased. Left knee joint urate volume decreased from 22.6 cm3 at baseline to 3.1, 1.2, and 0.2 cm3 at weeks 24, 36, and 52, respectively (urate depicted in green). Lateral femoral condyle bone erosion (arrows) decreased in size and showed evidence of healing with increased sclerosis and new bone formation. DECT, dual-energy computed tomography; BL, baseline; HAQ, Health Assessment Questionnaire; DI, disability index. Part D reproduced from Annals of the Rheumatic Diseases 80 (Suppl 1) 2021 with permission from BMJ Publishing Group Ltd

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Arthritis Research & Therapy

ISSN: 1478-6362

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