- The statistical outcomes for the interaction analyses of the lung (Fig. 2; females: 3-way mixed effects/males: 2-way ANOVA), talus (Fig. 3; females: 3-way mixed effects/males: 2-way ANOVA), and subchondral femur (Fig. 3; 2-way ANOVA) volume metrics are provided in tabular format. Significant effects (p<0.05) are shown in red