- We evaluated the direct effects of running distance and rate (Fig. 1) on the longitudinal micro-CT outcome measures of aerated lung (Fig. 2) and talus bone (Fig. 3) volumes by non-linear regression analysis. Total distance and running rate were significantly and negatively correlated with talus bone volumes for both female (distance: ρ=−0.614/rate: ρ=−0.594) and male (ρ=−0.903/ρ=−0.865) TNF-Tg mice (p<0.001). In addition, total distance and running rate were positively correlated with aerated lung volumes for female TNF-Tg (ρ=0.380 (p=0.061)/ρ=0.403 (p<0.05)) and WT (ρ=0.705/ρ=0.693 (p<0.01)) mice, but showed no relationship with males (p>0.05). Sample size is determined by number of limbs (talus) or animals (lung) at each time point evaluated. Significant effects (p<0.05) are shown in red
