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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: TRPA1 as a potential factor and drug target in scleroderma: dermal fibrosis and alternative macrophage activation are attenuated in TRPA1-deficient mice in bleomycin-induced experimental model of scleroderma

Fig. 5

Bleomycin enhanced the expression of M2 markers in J774 macrophages with or without IL-4. J774 macrophages were incubated for 24 h with increasing concentrations of bleomycin in the absence and in the presence of IL-4 (1 ng/ml). Arginase-1 (mArg-1; A and B) and mannose receptor C type 1 (mMRC-1; C and D). mRNA levels were measured with RT-PCR and normalized to GAPDH mRNA. WT control was given the value of 1 and the other values are set in the proportion to that value. Results are presented as mean + SEM; n = 4. *p < 0.05, **p < 0.01, ***p < 0.001 between the control (0) and the value beneath

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Arthritis Research & Therapy

ISSN: 1478-6362

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