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Table 5 Fetal outcomes in ART. Pa, comparisons among three groups. Pb, comparison between ART and planned pregnancy. Pc, comparison between ART and unplanned pregnancy. Pd, comparison between planned and unplanned pregnancy

From: Pregnancy outcomes in patients receiving assisted reproductive therapy with systemic lupus erythematosus: a multi-center retrospective study

 

ART (n = 65)

Planned (n = 201)

Unplanned (n = 23)

Pa

Pb

Pc

Pd

Outcomes

 Time of delivery, weeks, mean ± SD

36.8 ± 2.1

37.1 ± 2.0

34.8 ± 3.1

 < 0.001

0.267

0.001

 < 0.001

 Birth weight, mean ± SD

2653.5 ± 578.6

2703.3 ± 491.3

2298.3 ± 762.5

0.003

0.498

0.023

0.001

 IUGR, n (%)

5 (7.7)

17 (8.5)

4 (17.4)

0.383

   

 Fetal distress, n (%)

5 (7.7)

32 (15.9)

3 (13.0)

0.233

   

 LBW infants, n (%)

20 (30.8)

51 (25.4)

7 (30.4)

0.641

   

 VLBW infants, n (%)

2 (3.1)

5 (2.5)

5 (21.7)

0.001

0.680

0.012

0.001

 Neonatal hypoglycemia, n (%)

2 (3.1)

2 (1.0)

1 (4.3)

0.188

   

 Neonatal pneumonia, n (%)

3 (4.6)

3 (1.5)

1 (4.3)

0.702

   

 NRDS, n (%)

5 (7.7)

7 (3.5)

1 (4.3)

0.621

   

 Neonatal pathological jaundice, n (%)

11 (16.9)

29 (14.4)

2 (8.7)

0.702

   

 Malformation, n (%)

6 (9.2)

12 (6.0)

1 (4.3)

0.621

   

 PDA, n (%)

2 (3.1)

9 (4.5)

2 (8.7)

0.501

   

 PFO, n (%)

7 (10.8)

24 (11.9)

1 (4.3)

0.707

   

 ASD, n (%)

4 (6.2)

5 (2.5)

1 (4.3)

0.280

   

 Transfer to ICU, n (%)

10 (15.4)

70 (34.8)

8 (34.8)

0.011

0.003

0.070

1.000

Laboratory tests

 ANA, n (%)

12 (18.5)

24 (11.9)

4 (17.4)

0.313

   

 Anti-dsDNA, n (%)

5 (7.7)

11 (5.5)

3 (13.0)

0.244

   

 Anti-SSA, n (%)

6 (9.2)

12 (6.0)

3 (13.0)

0.265

   

 Anti-SSB, n (%)

2 (3.1)

0 (0)

1 (4.3)

0.028

0.059

1.000

0.103

  1. Abbreviation: ART Assisted reproductive therapy, ASD Atrial septal defect, ICU Intensive care unit, LBW Low-birth-weight, IUGR Intrauterine growth retardation, NRDS Neonatal respiratory distress syndrome, PDA Patent ductus arteriosus, PFO Patent foramen ovale, SD Standard deviation, VLBW Very-low-birth-weight