SARD | Followed ≥ 2 years | ||||||||
---|---|---|---|---|---|---|---|---|---|
ANA−HC | ANA+NS | UCTD | SARD (total) | SSc | SS | SLE | Non-progressors | Clinical progressors | |
N=50 | N=96 | N=64 | N=70 | N=22 | N=30 | N=16 | N= 42 | N=13 | |
Sex: female n(%) | 35 (70) | 91 (94.8) | 59 (92.2) | 65 (92.9) | 20 (90.9) | 27 (90) | 16 (100) | 40 (95.2) | 11 (84.6) |
Age: mean ± SD | 31.5 ± 11.5 | 43.2 ± 13.8 | 44.0 ± 15.0 | 49.4 ± 14.6a | 54.8 ± 13.5a,b | 51.7 ± 12.7a | 38.4 ± 14.9 | 43.0 ± 14.8 | 46.8 ± 11.4 |
Ethnicity:n(%) | |||||||||
Caucasian | 21 (42) | 58 (60.4) | 47 (73.4) | 49 (70) | 16 (72.7) | 23 (76.7) | 9 (56.3) | 29 (69.0) | 7 (53.8) |
Afro-Caribbean | 1 (2) | 13 (13.5) | 4 (6.3) | 1 (1.4)a | 0 (0) | 0 (0)a | 1 (6.3) | 3 (7.1) | 0 (0) |
East Asian | 2 (4) | 8 (8.3) | 5 (7.8) | 5 (7.1) | 1 (4.5) | 3 (10) | 1 (6.3) | 1 (2.4) | 1 (7.7) |
South Asian | 14 (28) | 13 (13.5) | 6 (9.4) | 8 (11.4) | 2 (9.1) | 3 (10) | 2 (12.5) | 5 (11.9) | 5 (38.5)c |
Hispanic | 9 (18) | 2 (2.1) | 2 (3.1) | 5 (7.1) | 3 (13.6)a | 1 (3.3) | 1 (6.3) | 2 (4.8) | 0 (0) |
Other | 0 (0) | 2 (2.1) | 0 (0) | 1 (1.4) | 0 (0) | 0 (0) | 1 (6.3) | 2 (4.8) | 0 (0) |
No data | 3 (6) | 0 (0) | 0 (0) | 1 (1.4) | 0 (0) | 0 (0) | 1 (6.3) | 0 (0) | 0 (0) |
Anti-Ro Ab+motherd:n(%) | 0 (0) | 8 (8.3) | 2 (3.1) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 2 (4.8) | 1 (7.7) |
ANA IF titer: median | 0 | 1/640 | 1/640 | >1/640 | >1/640 | 1/640 | 1/640 | 1/640 | 1/640 |
Number of specific Abs: mean ± SD | 0 | 0.76 ± 1.12 | 1.06 ± 1.14a | 1.88 ± 1.35a,b | 1.14 ± 0.85 | 2.00 ± 0.64a,b | 2.56 ± 2.19a,b | 0.74 ± 0.83 | 1.54 ± 1.51c |
Specific Abs:n(%) | |||||||||
dsDNA | 0 (0) | 8 (8.3) | 3 (4.7) | 9 (12.9) | 2 (9.1) | 3 (10) | 4 (25)b | 4 (9.5) | 0 (0) |
Ro | 0 (0) | 28 (29.2) | 20 (31.3) | 41 (58.6)a,b | 3 (13.6) | 30 (100)a,b | 8 (50) | 13 (31.0) | 7 (53.8) |
La | 0 (0) | 12 (12.5) | 4 (6.3) | 22 (31.4)a,b | 0 (0) | 21 (70)a,b | 1 (6.3) | 4 (9.5) | 4 (30.8) |
Sm | 0 (0) | 3 (3.1) | 3 (4.7) | 6 (8.6) | 0 (0) | 0 (0) | 5 (31.3)a,b | 0 (0) | 2 (15.4) |
SmRNP | 0 (0) | 4 (4.2) | 8 (12.5) | 9 (12.9) | 1 (4.5) | 0 (0) | 7 (43.8)a,b | 2 (4.8) | 2 (15.4) |
RNP | 0 (0) | 9 (9.4) | 12 (18.8) | 11 (15.7) | 1 (4.5) | 2 (6.7) | 7 (43.8)a,b | 2 (4.8) | 3 (23.1) |
Scl70 | 0 (0) | 1 (1) | 2 (3.1) | 9 (12.9)a | 5 (22.7)a,b | 2 (6.7) | 2 (12.5) | 2 (4.8) | 0 (0) |
Jo-1 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
Centromere | 0 (0) | 1 (1) | 7 (10.9)a | 16 (22.9)a | 13 (59.1)a,b | 1 (3.3) | 1 (6.3) | 1 (2.4) | 0 (0) |
Chromatin | 0 (0) | 7 (7.3) | 6 (9.4) | 8 (11.4) | 0 (0) | 1 (3.3) | 6 (37.5)a,b | 3 (7.1) | 2 (15.4) |
Ribosomal P | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
IFN5 score: median (IQR) | 48.6 (47.1–50.5) | 53.1 (48.9–63.0) | 53.1 (48.4–61.5) | 64.6 (53.4–68.5)a,b | 54.6 (49.7–60.1) | 67.4 (61.9–68.8)a,b | 65.5 (55.0–67.8)a,b | 52.9 (48.7–62.0) | 56.2 (49.2–64.8) |