Fig. 2
From: Osteoarthritis: a narrative review of molecular approaches to disease management
Effect of mechanical injury on mitochondria-associated pathways. Effects on MT dysfunction, oxidative response, and caspase activation leading to cell death, ECM degradation, and apoptosis and subsequently PTOA. Potential inhibitory roles of certain pharmacological interventions are depicted. Adapted from Delco et al. [15]. MT, mitochondria; ROS, reactive oxygen species; ECM, extracellular matrix