Table 2 Acute inflammatory phase mediators involved in OA
From: Osteoarthritis: a narrative review of molecular approaches to disease management
Cytokines: IL-1, IL-6, IL-8, 1L-17, TNF-α | |
Metalloproteinases: MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, ADAM-TS5 | |
Reactive oxygen species (ROS) | |
Caspases | |
Inflammatory cells (M1-macrophages, lymphocytes) | |
Cartilage degradation products (proteoglycan, collagen) | |
Innate immune cells |