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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Identification of anti-citrullinated osteopontin antibodies and increased inflammatory response by enhancement of osteopontin binding to fibroblast-like synoviocytes in rheumatoid arthritis

Fig. 4

Anti-cit-OPN antibody aggravates inflammatory arthritis. A Arthritis in DBA/1 mice immunized with ovalbumin or citrullinated osteopontin was induced by intraperitoneal injection of KBxN serum. B Time course of changes in the arthritis severity score and joint swelling. C, D Histologic sections from the ankle stained with hematoxylin and eosin staining (C) and assessed for the histologic synovitis scores (D) (n = 4–7 from two independent experiments). E Arthritis in SKG mice immunized with ovalbumin or citrullinated osteopontin was induced by mannan. F Time course of changes in the arthritis severity score and joint swelling. G, H Histological sections from the ankle stained with hematoxylin and eosin (G) and assessed for histological synovitis scores (H) (n = 6, from two independent experiments). All data are shown as the mean ± SEM. * p < 0.05 and *** p < 0.001 by Holm–Sidak test (B, F) or Mann–Whitney’s U test (D, H)

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Arthritis Research & Therapy

ISSN: 1478-6362

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