Fig. 3

Discovery of optimal thresholds for the top four most predictive histology features to discriminate synovial tissue samples from patients with OA from those with RA. A Raw histology feature scores in patients with OA and RA. B AUC curves extracted from Random Forest machine learning model. C Distribution of raw OA and RA histology feature scores and optimal threshold values extracted from Random Forest machine learning model. D Percent of OA and RA samples above or below optimal thresholds identified in C. OA osteoarthritis, RA rheumatoid arthritis, AUC area under the receiver operating characteristic curves