Fig. 2From: Levothyroxine use and longitudinal changes in thigh muscles in at-risk participants for knee osteoarthritis: preliminary analysis from Osteoarthritis Initiative cohortCausal mediation analysis. We evaluated the mediatory role (i.e., intermediary variable) of changes in the quantitative muscle markers of the thigh (baseline to 4th year) for the association between levothyroxine use (i.e., exposure variable) and incidence of KOA (baseline to 8th year) (i.e., outcome variable). KOA, knee osteoarthritisBack to article page