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Table 2 Longitudinal changes in thigh muscle markers between PS-matched levothyroxine users and non-users

From: Levothyroxine use and longitudinal changes in thigh muscles in at-risk participants for knee osteoarthritis: preliminary analysis from Osteoarthritis Initiative cohort

 

Average difference/year (95%CI), P

CSA (mm2)

intra-MAT CSA (mm2)

Contractile %

Specific strength

Total thigh muscles

− 22.23 (− 40.25 to − 4.21), P: 0.016

0.28 (− 4.16 to 4.73), P: 0.900

− 0.00 (− 0.05 to 0.05), P: 0.972

–

Quadriceps

− 16.06 (− 26.70 to − 5.41), P: 0.003*

1.07 (− 1.66 to 3.80), P: 0.443

− 0.02 (− 0.09 to 0.04), P: 0.438

− 0.01 (− 0.07 to 0.05), P: 0.709

Flexors

− 4.16 (− 10.95 to 2.63), P: 0.230

− 1.01 (− 3.49 to 1.48), P: 0.427

0.05 (− 0.04 to 0.13), P: 0.253

0.02 (− 0.03 to 0.07), P: 0.495

Adductors

− 1.74 (− 8.45 to 4.98), P: 0.613

0.03 (− 0.88 to 0.93), P: 0.952

− 0.02 (− 0.12 to 0.08), P: 0.703

–

Sartorius

− 0.25 (− 1.24 to 0.75), P: 0.625

0.04 (− 0.40 to 0.49), P: 0.857

0.00 (− 0.14 to 0.15), P: 0.962

–

  1. Longitudinal mixed-effect regressions were used to assess the difference in muscle biomarkers between PS-matched levothyroxine users and non-user participants
  2. CI confidence interval, CSA cross-sectional area, intra-MAT intra-muscular adipose tissue
  3. *P values that remained significant after FDR correction, indicative of a significant difference
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Arthritis Research & Therapy

ISSN: 1478-6362

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