Radiographic damage in early rheumatoid arthritis is associated with increased disability but not with pain—a 5-year follow-up study

Table 6 Relation between clinical and radiographic parameters and HAQ: generalized estimating equations

Variable	Crude	Adj. for sex and age	Multivariate model
Variable	β (95% CI)	β (95% CI)	β (95% CI)
Female sex	0.228 (0.086, 0.370)	-	0.229 (0.002, 0.456)
Age (per year)	0.006 (0.001, 0.011)	-	0.003 (−0.003, 0.009)
Symptom duration (months)	−0.027 (−0.052, −0.003)	−0.029 (−0.052, −0.005)	−0.027 (−0.056, 0.002)
RF seropositivity	−0.139 (−0.287, 0.009)	−0.101 (−0.245, 0.044)	-
Anti-CCP seropositivity	−0.092 (−0.252, 0.067)	−0.082 (−0.236, 0.072)	-
SJC28	*0.039 (0.030, 0.047)*	*0.039 (0.031, 0.048)*	0.011 (−0.001, 0.022)
TJC28	*0.038 (0.030, 0.045)*	*0.038 (0.031, 0.045)*
ESR (per mm/h)	*0.009 (0.007, 0.012)*	*0.009 (0.007, 0.012)*	0.004 (0.001, 0.008)
CRP (per mg/l)	*0.007 (0.005, 0.010)*	*0.008 (0.005, 0.010)*	-
SHS	−0.060 (−0.194, 0.075)	0.002 (−0.001, 0.005)	-
ES	0.009 (0.002, 0.016)	0.009 (0.002, 0.015)	0.010 (0.001, 0.020)
JSNS	0.002 (−0.003, 0.007)	0.001 (−0.004, 0.006)	-

Bold text indicates statistical significance with p-values <0.05. Italic text indicates p-values ≥0.05 and <0.10. Bold plus italic text indicates p-values <0.001. HAQ Health Assessment Questionnaire, CI confidence interval, RF rheumatoid factor, Anti-CCP anti-cyclic citrullinated peptide, SJC28 swollen joint count in 28 joints, TJC28 tender joint count in 28 joints, CRP C-reactive protein, ESR erythrocyte sedimentation rate, SHS Sharp-van der Heijde score, ES erosion score, JSNS joint space narrowing score

ISSN: 1478-6362