Fig. 5

OPLS-DA column loading plot (VIP > 1.0) demonstrating the difference between the two patient groups Airway abnormalities (including patients with coexisting nodules and/or ILA) and No PA, with respect to neutrophil activation status (CD11b and CD62L expression), neutrophil subtypes (% LDG and CD177 expression), calprotectin, as well as disease activity measures and demographic data (A). Subsequent univariate analysis of airway abnormalities and CD11b (B), CD62L (C), RF (D), ACPA (E), CRP (F) and ESR (G). Bars show median. ns, non-significant, *p ≤ 0.05, **p ≤ 0.01, *** p ≤ 0.001 (Mann–Whitney U test)