Table 5 Genotype and allele distribution in OA patients and healthy controls
From: Metformin attenuates symptoms of osteoarthritis: role of genetic diversity of Bcl2 and CXCL16 in OA
SNP | Â | Frequencies (%) | Pc | OR; 95%CI | Pa | OR; 95%CI | ||
|---|---|---|---|---|---|---|---|---|
Subjects | OA | Control (n = 92) | ||||||
Metformin (n = 44) | Placebo (n = 44) | |||||||
| Â | Genotype | Â | Â | Â | Â | Â | Â | Â |
938C>A (Bcl-2) | CC | 21 (47.7) | 28 (63.6) | 28 (30.4) | 0.0008 | 2.9; 1.9–5.4 | 0.001 | 5.2; 2.0–13.7 |
CA | 15 (34.1) | 12 (27.3) | 54 (58.7) | |||||
AA | 8 (18.2) | 4 (9.1) | 10 (10.9) | |||||
Allele | Â | Â | Â | Â | Â | Â | Â | |
C | 57 (64.8) | 68 (77.3) | 110 (59.8) | 0.02 | 1.7; 1.1.–2.6 | 0.04 | 2.2; 1.1–9.8 | |
A | 31 (35.2) | 20 (22.7) | 74 (40.2) | |||||
| Â | Genotype | Â | Â | Â | Â | Â | Â | Â |
A181V (CXCL-16) | GG | 20 (45.5) | 20 (45.5) | 28 (30.5) | 0.007 | 3.4; 1.4–8.5 | 0.04 | 2.1; 1.1–10.5 |
GA | 19 (43.2) | 22 (50.0) | 43 (46.7) | |||||
AA | 5 (11.3) | 2 (4.5) | 21 (22.8) | |||||
Allele | Â | Â | Â | Â | Â | Â | Â | |
G | 59 (67.0) | 62 (70.5) | 99 (53.8) | 0.004 | 1.9; 1.2–2.9 | 0.02 | 2.2; 1.1–4.8 | |
A | 29 (33.0) | 26 (29.5) | 85 (46.2) | |||||