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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo

Fig. 6

TAK-715 inhibited p38MAPK pathway activation and alleviated ECM degradation in ex vivo IVD culture model. A Representative HE and SO/FG staining of ex vivo IVD (scale bar:200 μm); B the histological grades were evaluated (n = 5) C IHC was used to determine the protein expression of p-p38 and Collagen II (upper scale bar:200 μm, lower scale bar:20 μm). D, E The protein expression of p-p38 and collagen II was quantitatively analyzed (n = 3). The data are presented as the mean ± SD (*P < 0.05; **P < 0.01; ***P < 0.001)

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Arthritis Research & Therapy

ISSN: 1478-6362

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