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Table 2 Effect estimates of the associations between RA and hepatocellular carcinoma

From: The genetic liability to rheumatoid arthritis may decrease hepatocellular carcinoma risk in East Asian population: a Mendelian randomization study

Method

SNPs (N)

OR

95%CI

MR p-value

Heterogeneity O/p-value

Pleiotropy intercept p-value

IVW

42

0.864

0.785 ~ 0.952

0.003

53.22/0.095

 

Weighted median

42

0.809

0.709 ~ 0.923

0.002

  

Weighted mode

42

0.850

0.736 ~ 0.982

0.032

  

Simple median

42

0.919

0.792 ~ 1.066

0.267

  

MR-Egger

42

0.855

0.708 ~ 1.031

0.109

 

0.892b

MR-PRESSO

42

/

/

0.049a

 

0.099

  1. SNP single nucleotide polymorphism, OR odds ratio, CI confidence interval, IVW inverse-variance weighted, MR Mendelian randomization, MR-PRESSO MR pleiotropy residual sum and outlier
  2. ap-value of the intercept from MR-Egger regression analysis
  3. bp-value of MR-PRESSO global test