Fig. 1
From: Mouse models of systemic juvenile idiopathic arthritis and macrophage activation syndrome
Temporal overview of mouse models of SJIA and MAS. A Repeated TLR-9 stimulation model. B IL-6 transgenic mice with TLR stimulation model. C IFN-γ knockout mice with CFA stimulation model. D IL1RN − / − and Tsc2-knock out models. E NSGS mice with xenograft models. F CD40 stimulated mice model. WT: wild type, i.p.: Intraperitoneal injection, IL-18BP: Interleukin-18-binding protein, KO: knock out, Tg: transgenic, IFN-γ: interferon gamma, CFA: Freund’s complete adjuvant, s.c.: subcutaneous injection, UCB: umbilical cord blood, hHSC: human hematopoietic stem cells