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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Mechanical overloading-induced miR-325-3p reduction promoted chondrocyte senescence and exacerbated facet joint degeneration

Fig. 1

Chondrocyte senescence is associated with lumbar facet joint degeneration in human and mice. A, B Representative histological images of human LFJ cartilage with hematoxylin–eosin (H&E) and safranin O/fast green in normal and degenerative groups. Scale bar = 200 μm. C Quantitative analysis of Osteoarthritis Research Society International (OARSI) score in B and D, E Representative immunohistochemistry images of p53 and p21 in human LFJ cartilage in normal and degenerative groups. Scale bar = 200 μm. F, G Quantitative analysis of p53 and p21 in D and E. H, I Representative histological images of LFJ cartilage with hematoxylin–eosin (H&E) and Safranin O/Fast Green in sham and standing 10 weeks groups in mice. Scale bar = 50 μm. J Quantitative analysis of OARSI score in I. K, L Representative immunohistochemistry images of p53 and p21 in LFJ cartilage in sham and standing 10 weeks groups in mice. Scale bar = 50 μm. M, N Quantitative analysis of p53 and p21 in K and L. n = 6 per group. All data are shown as the mean ± standard deviation (SD). *P < 0.05, **P < 0.01

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