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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Notch signaling is activated in knee-innervating dorsal root ganglia in experimental models of osteoarthritis joint pain

Fig. 2

Effects of activation of Notch signaling on TLR4-mediated increases of CCL2 in DRG cell cultures. A NICD IF staining of DRG cells cultured with immobilized Jag1-Fc for 4 days. Representative images from each culture group are shown (N = 9 cultures per group). Scale bars, 50 μm. B-D Effects of activating Notch signaling with immobilized Jag1-Fc on LPS-induced NICD MFI (B), Ccl2 mRNA (C), and CCL2 protein (D) (N = 6–9 per group). The controls were immobilized with IgG-Fc

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Arthritis Research & Therapy

ISSN: 1478-6362

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