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Fig. 7 | Arthritis Research & Therapy

Fig. 7

From: Notch signaling is activated in knee-innervating dorsal root ganglia in experimental models of osteoarthritis joint pain

Fig. 7

Activated Notch protein (NICD) is increased in DRGs of mice after DMM surgery. A ELISA assessment of NICD in tissue lysates of pooled L3-L5 DRGs from mice 12 and 26 weeks after DMM or sham surgery (N = 4–7 mice per group). NICD levels are presented as absorbance at 450 nm normalized to total proteins. B, C NICD immunofluorescence staining in the L4-DRG from mice 12 weeks (B) and 26 weeks (C) after DMM or sham surgery. Representative images of each group are shown (N = 3 mice per group). Scale bars, 25 μm. Fluorescence signals were quantified as mean fluorescence intensity (MFI) (each dot represents one mouse)

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Arthritis Research & Therapy

ISSN: 1478-6362

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