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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Activated CD90/Thy-1 fibroblasts co-express the Δ133p53β isoform and are associated with highly inflamed rheumatoid arthritis

Fig. 2

RA samples with elevated Δ133TP53 and TP53β mRNA expression are associated with high immune infiltration. A Hierarchical clustering analysis of RA joint tissue by mRNA expression of FL/Δ40TP53_T1, FL/Δ40TP53_T2, Δ133TP53, TP53α and TP53β. The coloured label bars on the top indicate the amount of infiltration of CD68+ cells, CD3+ T cells and CD20.+ B cells (warm colours: high infiltration; cool colours: low infiltration). The bar graph represents the number of RA patient samples from each of the RA subtypes that fall within the groups G1, G2 or G3, determined by rank hierarchical clustering. B Immunoscore vs transcript expression for each patient sample. C Transcript expression of Δ133TP53, TP53β, FL/Δ40TP53_T1, FL/Δ40TP53_T2 and TP53α. Dots in B and C represent the individual data points in each group. The lines represent the mean and SD. Significance was determined using an unpaired t test with Welch’s correction. *p < 0.05; **p < 0.01

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