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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Activated CD90/Thy-1 fibroblasts co-express the Δ133p53β isoform and are associated with highly inflamed rheumatoid arthritis

Fig. 5

RA synovial tissue with elevated Δ133TP53 and TP53β transcript expression is associated with elevated levels of plasma cytokines. A, B Hierarchical clustering analysis of RA synovial tissue by mRNA expression of FL/Δ40TP53_T1, FL/Δ40TP53_T2, Δ133TP53, TP53α and TP53β. A Fifteen Th17-related plasma cytokines. B Four selected plasma cytokines. The scale labels along the top indicate the amount of infiltration of CD68+ cells, CD3+ T cells and CD20+ B cells (warm colours: high infiltration; cool colours: low infiltration). C Levels of 6 serum cytokines (IL-6, TNF-α, IL-12(p70), IFN-γ, IL-1a and IL-1b) from 9-week-old Δ122p53 + / − (blue) and p53 + / − (red) mice. Shown are the mean concentrations of each cytokine from serum pooled from 4 individual mice with error bars at 97% CI. Significance was determined using an unpaired t test with Welch’s correction; *p < 0.05

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