Fig. 6

Model proposing how Δ133p53β orchestrates CD90 cell migration in RA. A Graphical representation of the normal and RA joint synovia. B The inflammatory milieu invokes a TP53 response leading to an upregulation of Δ133p53β in FLS. This leads to cytokine secretion, including IL-6, sustaining a pro-inflammatory microenvironment. Downstream effects include the expansion and persistence of T_h17 cells vs T_regs and the recruitment and activation of CD90⁺ FLS, resulting in their migration through the CD90⁺ perivasculature facilitated by CD90⁺ endothelial cells