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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Re-thinking osteoarthritis pathogenesis: what can we learn (and what do we need to unlearn) from mouse models about the mechanisms involved in disease development

Fig. 2

Simplified schematic of the Wnt signalling pathway. Wnt signalling occurs through canonical and non-canonical pathways. Two of the major non-canonical pathways are Wnt/CaMKII and Wnt/PCP. Members of the Wnt ligand family can bind to a multitude of different receptors. Different Wnt ligand/receptor combinations lead to differences in the relative amount of canonical and non-canonical pathway activation. The figure was created using Biorender.com

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Arthritis Research & Therapy

ISSN: 1478-6362

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