Skip to main content
Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Re-thinking osteoarthritis pathogenesis: what can we learn (and what do we need to unlearn) from mouse models about the mechanisms involved in disease development

Fig. 3

Comparison of the changes in Wnt signalling pathway activity observed in animal models of OA compared to human disease. Observations regarding Wnt signalling activity in human disease have been largely limited to late-stage disease. Findings from animal models may aid in predicting the changes in Wnt signalling that occur during early-stage disease in humans (grey text). Differences in Wnt signalling between injury-induced animal models of OA and the STR/ort mouse may suggest that Wnt signalling also differs between patients with post-traumatic OA compared to other forms of OA. The figure was created using Biorender.com

Back to article page