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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Glutathione peroxidase 3 is a novel clinical diagnostic biomarker and potential therapeutic target for neutrophils in rheumatoid arthritis

Fig. 4

Co-expression network constructed by WGCNA based on the combined data from GSE154474, GSE93776, and GSE116899. A The soft-thresholding power (β) of 16 was chosen based on the scale-free topology criterion in normalized data from (B) clustering dendrogram of samples with clinical traits heatmap. C Identification of meta-module and relationships among module-module. D Heatmap showing module-trait relationship of magenta module and clinical traits (columns). E Scatter plot of gene significance (GS) for RA SF vs. module membership (MM) in the co-expression paleturquoise module. F Construction and visualization of a WGCNA co-expression network by Cytoscape software and screening hub genes. G ALDOA, ENO1, GAPDH, PKM, and GPX3 mRNA levels were determined by qPCR

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