Table 2 Regression models for all the diseases together

Female sex

0.67

(0.43–1.04)

0.073

0.68

(0.40–1.13)

0.138

Age at onset

0.99

(0.97–1.01)

0.202

1.01

(0.99–1.03)

0.489

Disease (ref RA)

AS

1.48

(0.82–2.68)

0.19

0.98

(0.52–2.31)

0.802

PsA

2.40

(1.45–3.97)

0.001

1.96

(1.10–3.50)

0.023

TNF-i (ref remaining treatments)

2.82

(1.35–5.87)

0.006

1.43

(0.63–3.25)

0.397

Smoking (ref smoker)

Non-smoker

2.43

(1.20–4.89)

0.013

2.48

(1.21–5.08)

0.013

Ex-smoker

0.47

(0.10–2.18)

0.335

0.63

(0.13–2.97)

0.556

Second line of treatment (vs first line)

0.97

(0.62–1.53)

0.902

1.52

(0.93–2.49)

0.098

Disease duration

0.97

(0.93–1.00)

0.037

0.95

(0.91–0.99)

0.006

Concomitant csDMARD

0.60

(0.39–0.94)

0.026

0.56

(0.34–0.92)

0.021

Moderate-high activity^a

1.44

(0.38–5.39)

0.591

Time on treatment with the previous biologic agent

1.01

(1.01–1.02)

 < 0.001

1.01

(1.01–1.02)

 < 0.001

Year of discontinuation of treatment

0.98

(0.93–1.02)

0.309

0.96

(0.91–1.02)

0.157