A higher intramuscular fat in vastus medialis is associated with functional disabilities and symptoms in early stage of knee osteoarthritis: a case–control study

Table 3 Association of quadriceps muscle volume and intraMAT with KSS function, symptom, and WORMS

	B	95% CI	β	p-value
Association with KSS function scores
Quadriceps muscle volume	− 0.00	[− 0.02, 0.02]	− 0.03	0.913
Quadriceps intraMAT	− 3.88	[− 5.93, − 1.82]	− 0.54	< 0.001
Presence of early knee OA	− 6.79	[− 13.21, − 0.38]	− 0.30	0.038
Age	− 0.02	[− 0.49, 0.44]	− 0.01	0.917
Sex	− 0.77	[− 10.99, 9.46]	− 0.03	0.881
Body mass index	− 0.03	[− 1.82, 1.75]	− 0.01	0.970
Association with KSS symptom scores
Quadriceps muscle volume	0.00	[− 0.01, 0.01]	0.07	0.776
Quadriceps intraMAT	− 0.52	[− 1.07, 0.03]	− 0.26	0.061
Presence of early knee OA	− 4.28	[− 5.92, − 2.57]	− 0.60	< 0.001
Age	0.05	[− 0.07, 0.17]	0.09	0.415
Sex	0.40	[− 2.32, 3.13]	0.06	0.768
Body mass index	− 0.03	[− 0.51, 0.45]	− 0.02	0.899
Association with WORMS
Quadriceps muscle volume	− 0.01	[− 0.04, 0.02]	− 0.20	0.517
Quadriceps intraMAT	− 1.19	[− 3.80, 1.43]	− 0.16	0.365
Presence of early knee OA	4.65	[− 3.52, 12.81]	0.17	0.258
Age	0.76	[0.17, 1.35]	0.38	0.013
Sex	− 2.42	[− 15.44, 10.60]	− 0.09	0.709
Body mass index	1.69	[− 0.59, 3.96]	0.31	0.142

Multiple linear regression analyses were conducted with KSS function, symptom, and WORMS as the dependent variable and quadriceps muscle volume, intraMAT, and the presence of early knee OA as the dependent variable, with adjustments for age, sex, and BMI
KSS Knee Scoring System, WORMS Whole-organ magnetic resonance imaging scoring, OA Osteoarthritis, SE Standard error, 95% CI 95% confidence interval, IntraMAT Intramuscular fat

ISSN: 1478-6362