A higher intramuscular fat in vastus medialis is associated with functional disabilities and symptoms in early stage of knee osteoarthritis: a case–control study

Table 4 Association of VM muscle volume and intraMAT with KSS function, symptom, and WORMS

	B	95% CI	β	p-value
Association with KSS function score
VM muscle volume	− 0.00	[− 0.09, 0.08]	− 0.01	0.955
VM intraMAT	− 3.47	[− 5.24, − 1.71]	− 0.62	< 0.001
Presence of early knee OA	− 2.91	[− 10.05, 4.22]	− 0.11	0.415
Age	− 0.05	[− 0.50, 0.39]	− 0.03	0.807
Sex	− 0.76	[− 10.21, 8.68]	− 0.03	0.871
Body mass index	− 0.11	[− 1.83, 1.61]	− 0.02	0.897
Association with KSS symptom score
VM muscle volume	− 0.00	[− 0.02, 0.02]	0.01	0.900
VM intraMAT	− 0.63	[− 1.09, − 0.17]	− 0.40	0.008
Presence of early knee OA	− 3.33	[− 5.20, − 1.47]	− 0.46	0.001
Age	0.05	[− 0.07, 0.17]	0.09	0.386
Sex	0.12	[− 2.35, 2.59]	0.02	0.923
Body mass index	0.06	[− 0.39, 0.51]	0.04	0.777
Association with total WORMS
VM muscle volume	− 0.06	[− 0.16, 0.05]	− 0.30	0.295
VM intraMAT	− 1.67	[− 3.93, 0.59]	− 0.28	0.143
Presence of early knee OA	7.21	[− 1.93, 16.36]	0.27	0.119
Age	0.77	[0.20, 1.34]	0.39	0.009
Sex	− 3.51	[− 15.61, 8.60]	− 0.14	0.562
Body mass index	2.06	[− 0.15, 4.26]	0.37	0.066

Multiple linear regression analyses were conducted with KSS function, symptom, and WORMS as the dependent variable and VM muscle volume, intraMAT, and the presence of early knee OA as the dependent variable, with adjustments for age, sex, and BMI
KSS Knee Scoring System, WORMS Whole-organ magnetic resonance imaging scoring, VM Vastus medialis, OA Osteoarthritis, SE Standard error, 95% CI 95% confidence interval, IntraMAT Intramuscular fat

ISSN: 1478-6362