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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Multi-omics profiling reveals potential alterations in rheumatoid arthritis with different disease activity levels

Fig. 2

Analysis of characteristic plasma metabolites in RA with different disease activity levels. A, C Heat maps of correlation between characteristic metabolites in anionic (A) and cationic (C) modes and clinical indicators of RA. Spearman was used for correlation analysis. Red represents a positive correlation and blue represents a negative correlation. B, D The box plot showed that characteristic metabolites of anionic (B) and cationic (D) modules significantly changed between RA with different disease activity levels according to Wilcoxon rank-sum test. Boxes represent the inter-quartile ranges, and lines inside the boxes denote medians. E–I Differential metabolites of DAS28L vs. HC (E), DAS28M vs. HC (F), DAS28H vs. HC (G), DAS28M vs. DAS28L (F), and DAS28H vs. DAS28M (I) were enriched in KEGG pathway. The color bars indicate enrichment significance levels. P-value, *p < 0.05, **p < 0.01, ***p < 0.001

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