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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Multi-omics profiling reveals potential alterations in rheumatoid arthritis with different disease activity levels

Fig. 3

Changes of gut bacteria and fungi between RA with different disease activity levels. A, B The distribution plot of relative abundance at the genus level of bacteria (A) and fungi (B). C–E Relative abundance of Candida (C), Lactobacillus (D), and Escherichia-Shigella (E) in the HC group and RA with different disease activity levels groups. F Intestinal bacterial PICRUSt2 function predicts changes in linoleic acid metabolism pathway in RA progression. G, H LefSe analysis was used to identify highly differentiated taxa for RA gut bacteria (G) and fungi (H) with different disease activity levels and to display LDA scores. The bar chart shows the mean value of each group. Error bars represent the standard error of the mean values. RA, rheumatoid arthritis; HC, healthy controls; PICRUSt2, Phylogenetic Investigation of Communities by Reconstruction of Unobserved States; LefSe, linear discriminant analysis (LDA) effect size; P-value, *p < 0.05, **p < 0.01, ***p < 0.001. NS, not significant

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